Health
WHO recommends dolutegravir as preferred HIV treatment option in all populations
Based on new evidence assessing benefits and risks, the World Health Organization (WHO) recommends the use of the HIV drug dolutegravir (DTG) as the preferred first-line and second-line treatment for all populations, including pregnant women and those of childbearing potential.
Initial studies had highlighted a possible link between DTG and neural tube defects (birth defects of the brain and spinal cord that cause conditions such as spina bifida) in infants born to women using the drug at the time of conception. This potential safety concern was reported in May 2018 from a study in Botswana that found 4 cases of neural tube defects out of 426 women who became pregnant while taking DTG. Based on these preliminary findings, many countries advised pregnant women and women of childbearing potential to take efavirenz (EFV) instead.
New data from two large clinical trials comparing the efficacy and safety of DTG and EFV in Africa have now expanded the evidence base. The risks of neural tube defects are significantly lower than what the initial studies may have suggested.
The guidelines group also considered mathematical models of the benefits and harms associated with the two drugs; the values and preferences of people living with HIV, as well as factors related to implementation of HIV programmes in different countries, and cost.
DTG is a drug that is more effective, easier to take and has fewer side effects than alternative drugs that are currently used. DTG also has a high genetic barrier to developing drug resistance, which is important given the rising trend of resistance to EFV and nevirapine-based regimens. In 2019, 12 out of 18 countries surveyed by WHO reported pre-treatment drug resistance levels exceeding the recommended threshold of 10%.
All of above findings informed the decision to update the 2019 guidelines.
In 2019, 82 low- and middle-income countries reported to be transitioning to DTG-based HIV treatment regimens. The new updated recommendations aim to help more countries improve their HIV policies.
As for any medications, informed choice is important. Every treatment decision needs to be based on an informed discussion with the health provider weighing the benefits and potential risks.
WHO also stresses the importance of providing information and options to help women make an informed choice. To this end WHO has convened an advisory group of women living with HIV from diverse backgrounds to advise on policy issues related to their health, including sexual and reproductive health. WHO highlights the need to continually monitor the risk of neural tube defects associated with DTG.
The lawmaker representing Ibarapa East/Ido Federal Constituency in the House of Representatives, Aderemi Oseni, has pledged to support the breast cancer awareness programme of the ABC Foundation founded by former Oyo First Lady, Dr. Florence Ajimobi.
Oseni, who is Chairman of the House Committee on Federal Roads Maintenance Agency (FERMA), made the commitment on Thursday in Ibadan at the flag-off of Pink Month 2025, an initiative of the foundation.
Contained in a statement by his media aide, Idowu Ayodele, the lawmaker described the campaign as a “lifesaving mission” given the rising burden of breast cancer in Nigeria, with over 28,000 new cases and thousands of deaths reported annually.
The APC chieftain said the free screening of 1,000 women planned by the foundation was timely, stressing that early detection remained the strongest weapon in the fight against cancer.
Hon. Aderemi Oseni exchanging pleasantries with former Oyo State First Lady, Dr. (Mrs.) Florence Ajimobi, at the event.
“Health is life. Only this June, I moved a motion at the National Assembly which led to the Federal Government subsidising dialysis treatment nationwide. Today, dialysis is either free or heavily discounted in federal health facilities,” Oseni said.
He listed his personal interventions to include funding hospital bills of indigent patients, construction of hospitals in Ido and Ibarapa East, establishment of primary health centres, and organisation of medical outreaches. He also disclosed plans to deploy mobile clinics to rural areas.
Commending Mrs. Ajimobi for sustaining her late husband’s legacy through humanitarian service, Oseni assured of partnership with the foundation, saying women’s wellbeing and empowerment remained central to his vision for Oyo State.
In her remarks, Mrs. Ajimobi said the foundation had offered medical care to over 85,000 patients and conducted more than 100,000 investigations since its inception. She added that the campaign was not just corporate social responsibility but “a moral duty and sacred trust.”
The former first lady, who lost her daughter Abisola to breast cancer earlier this year, said the experience had strengthened her resolve to save other families from such tragedy. She appealed to women to take advantage of the free screening and called on partners and development agencies to support the fight.
Chairman of Fidson Healthcare Plc, Dr. Fidelis Akhagboso Ayebae, and Chief Executive Officer of Hazon Holdings, Dr. Victor ’Gbenga Afolabi, are set to lead discussions at the second edition of the D’Bio Wellness & Selfcare Summit.
The event is scheduled to hold on September 24 and 25 at the Lagos Chamber of Commerce and Industry (LCCI) Conference and Exhibition Centre, Alausa, Ikeja.
This year’s summit has the theme: “Self-Care as a Driver of Optimal Health and Wellness.”
Ayebae will serve as chairman of the event, while Afolabi, who is also the co-founder of Wellness HMO, will deliver the keynote address.
Ayebae, founder of Fidson Healthcare, is regarded as one of Nigeria’s leading pharmaceutical entrepreneurs. He is a fellow of the Institute of Directors Nigeria and the Institute of Corporate Affairs Management, and has held significant roles in the Manufacturers Association of Nigeria.
Afolabi has more than 20 years’ experience spanning healthcare, finance, technology and marketing. He is also the founder of the Eko Innovation Centre, a Lagos-based technology hub that supports start-ups and young entrepreneurs.
Convener of the summit, Dr. Monica Hemben Eimunjeze, said the event would focus on practical steps to improve health outcomes through self-care.
She said, “We are excited to welcome Dr. Ayebae and Dr. Afolabi as pivotal figures in our quest to enhance health literacy and empower individuals to prioritise self-care. This summit is not just about discussions; it is about actionable insights that can inspire and transform lives.”
The organisers said the two-day summit is open to the public and will feature panel sessions with health and wellness experts, attracting healthcare professionals, advocates and business leaders.
The Federal College of Animal Health and Production Technology, Moor Plantation, Apata, Ibadan, has joined the campaign to eradicate malaria in Nigeria.
The initiative followed the unveiling of the Geneith Health Competition on the institution’s campus on Tuesday.
The competition, organised by CEOAfrica in partnership with Geneith Pharmaceuticals Limited and powered by Coatal Forte Softgel, targets students of tertiary and secondary schools nationwide to spread knowledge on malaria prevention.
Convener of the project, Mr. Cletus Ilobanafo, said the programme was designed to raise awareness through a structured health contest at the state, regional and national levels.
He said Geneith Pharmaceuticals has committed N1 billion to the project, with N400 million earmarked for scholarships and N600 million for gift items to motivate participants. “By promoting education and prevention strategies, this competition underscores the dedication of all stakeholders in combating malaria and improving public health in Nigeria,” Ilobanafo added.
The Provost of the College, Dr. Chidi Okpeze, praised the organisers for selecting the institution as a launch platform for the campaign. He expressed gratitude to President Bola Tinubu and Minister of Livestock Development, Alhaji Idi Mukhtar Maiha, for their commitment to repositioning the livestock sector to boost national growth.
“Our students are ready to key into this initiative. They are articulate, active, and have represented us well in international competitions. We are confident they will excel in this campaign too,” he said.
The Provost urged the students to brace up for the task ahead and uphold the institution’s tradition of excellence.
Some students, who spoke on behalf of their colleagues, pledged to support the anti-malaria campaign by intensifying environmental sanitation on campus. They also commended the organisers and sponsors for giving them the opportunity to contribute to the fight against malaria.
They promised to sustain clean surroundings and spread the message beyond the school to ensure malaria is eradicated from the system.
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