Health
WHO recommends dolutegravir as preferred HIV treatment option in all populations
Based on new evidence assessing benefits and risks, the World Health Organization (WHO) recommends the use of the HIV drug dolutegravir (DTG) as the preferred first-line and second-line treatment for all populations, including pregnant women and those of childbearing potential.
Initial studies had highlighted a possible link between DTG and neural tube defects (birth defects of the brain and spinal cord that cause conditions such as spina bifida) in infants born to women using the drug at the time of conception. This potential safety concern was reported in May 2018 from a study in Botswana that found 4 cases of neural tube defects out of 426 women who became pregnant while taking DTG. Based on these preliminary findings, many countries advised pregnant women and women of childbearing potential to take efavirenz (EFV) instead.
New data from two large clinical trials comparing the efficacy and safety of DTG and EFV in Africa have now expanded the evidence base. The risks of neural tube defects are significantly lower than what the initial studies may have suggested.
The guidelines group also considered mathematical models of the benefits and harms associated with the two drugs; the values and preferences of people living with HIV, as well as factors related to implementation of HIV programmes in different countries, and cost.
DTG is a drug that is more effective, easier to take and has fewer side effects than alternative drugs that are currently used. DTG also has a high genetic barrier to developing drug resistance, which is important given the rising trend of resistance to EFV and nevirapine-based regimens. In 2019, 12 out of 18 countries surveyed by WHO reported pre-treatment drug resistance levels exceeding the recommended threshold of 10%.
All of above findings informed the decision to update the 2019 guidelines.
In 2019, 82 low- and middle-income countries reported to be transitioning to DTG-based HIV treatment regimens. The new updated recommendations aim to help more countries improve their HIV policies.
As for any medications, informed choice is important. Every treatment decision needs to be based on an informed discussion with the health provider weighing the benefits and potential risks.
WHO also stresses the importance of providing information and options to help women make an informed choice. To this end WHO has convened an advisory group of women living with HIV from diverse backgrounds to advise on policy issues related to their health, including sexual and reproductive health. WHO highlights the need to continually monitor the risk of neural tube defects associated with DTG.
Health
Oyo: Tragedy As Bride-to-Be Among Four Dead in Suspected Lassa Fever Outbreak
The Oyo State Ministry of Health has closed two hospitals in Saki West Local Government Area following a suspected outbreak of Lassa fever, which has claimed four lives.
The fatalities, confirmed by the Oyo State Rapid Response Team (RRT), include three males and a 32-year-old female who was preparing for her wedding. The closure of the hospitals aims to contain the spread of the disease and ensure thorough decontamination.
In a press statement issued by the Commissioner for Information and Orientation, Dotun Oyelade, the State Commissioner for Health, Dr. Oluwaserimi Ajetunmobi, revealed that the RRT was dispatched to Saki following distress calls from residents reporting mysterious deaths.
Findings and Immediate Actions
The RRT, comprising health officials, representatives from WHO and the Red Cross, and local health authorities, conducted a comprehensive investigation into the outbreak.
Preliminary findings suggest that an apprentice at one of the affected hospitals, who had recently returned from Iwajowa Local Government Area, might have introduced the infection.
The team disclosed that the deceased exhibited symptoms consistent with Lassa fever, such as craniofacial bleeding. The hospital owner, who was among the deceased, initially self-medicated with antimalarials and antibiotics before seeking hospital care when his condition worsened.
Containment Measures
Both the hospital where the fatalities occurred and the facility that admitted the hospital owner were shut down for decontamination.
Contact tracing efforts are ongoing, focusing on high-risk individuals who had contact with the deceased during their illness or burial.
Affected health workers were trained on Infection Prevention and Control (IPC) protocols, and public awareness campaigns were conducted to educate residents about Lassa fever.
Samples have been collected from a symptomatic individual, pending laboratory confirmation. Line-listing of contacts is underway to identify potential cases and prevent further spread.
Collaborative Efforts
The RRT also paid an advocacy visit to the Okere of Saki’s palace to brief traditional authorities on the situation. Local government officials in Saki West were engaged to coordinate containment strategies.
Reports indicate that while the outbreak initially affected Saki West, it has extended to Iwajowa and Kajola Local Government Areas.
Disease Surveillance and Notification Officers (DSNOs) in the affected LGAs have been instructed to commence preliminary containment measures as the State RRT ramps up its response.
Call for Vigilance
The Ministry of Health has urged residents to remain vigilant, report any symptoms suggestive of Lassa fever, and adhere to preventive measures.
These include proper hygiene practices, avoiding contact with rodents, and seeking medical attention promptly if symptoms arise.
Health
Oyo: Oseni to Launch Mobile Clinic Initiative to Revitalize Rural Healthcare
A member representing Ibarapa East/Ido federal constituency of Oyo State at the House of Representatives, Engr. Aderemi Oseni, has announced a plan to launch a “Mobile Clinic” programme aimed at providing essential healthcare services directly to rural communities across the constituency.
Scheduled to begin in the first quarter of 2025, this initiative underscores Oseni’s commitment to expanding healthcare access, particularly for underserved populations.
Speaking on Saturday at the 10th-anniversary celebration of God’s Knot Hospital in Ologuneru, Ibadan, the lawmaker, who also chairs the House Committee on the Federal Roads Maintenance Agency (FERMA), highlighted the programme’s primary objective: bringing healthcare closer to the people.
“Every community deserves attention; healthcare should never be bound by geographical barriers,” Oseni stated.
He explained that the mobile clinics would deliver essential health check-ups, screenings, and preventive care in remote areas, allowing residents to access quality healthcare without traveling long distances.
As part of his broader healthcare agenda, Oseni informed, through a statement by his media aide, Idowu Ayodele, that he has already facilitated the construction of two fully equipped maternity centers within his constituency, both slated for commissioning before December 2024. He also disclosed plans to establish two modern general hospitals in 2025, further strengthening his commitment to building a healthier community.
The lawmaker expressed interest in collaborating with God’s Knot Hospital on the mobile clinic project, calling for partnerships to support sustainable healthcare initiatives that enhance the quality of life for vulnerable populations in the constituency.
“I resonate deeply with the mission of God’s Knot Hospital,” Oseni shared, adding that such partnerships would significantly improve healthcare in Oyo State”.
The anniversary event attracted distinguished guests, including former Ondo State Governor Dr. Olusegun Mimiko, whom Oseni commended for his contributions to healthcare, particularly through the Mother and Child Hospitals that transformed maternal and child healthcare in Ondo State.
Oseni urged philanthropists, government bodies, and international organizations to support healthcare projects like the upcoming mobile clinics, emphasising that the improvement of healthcare services is a shared responsibility.
Health
NAFDAC Shuts Maiduguri Market Over Sun-Dried Drugs After Flood
The National Agency for Food and Drug Administration and Control (NAFDAC) has ordered the immediate closure of the Gomboru drug market in Maiduguri following severe flooding that submerged the area and contaminated the drugs sold within the market.
In a statement posted on its official X handle, NAFDAC disclosed that the decision was made after reports surfaced that contaminated drugs, which had been washed and sun-dried for resale, were being sold at the market.
“After the recent flooding in Maiduguri that submerged the Gomboru drug market where contaminated drugs were washed and sun-dried for resale, the @DGatNAFDAC ordered the immediate closure of the market to conduct a thorough shop-to-shop removal of these compromised drugs,” the agency wrote.
The flooding, which ravaged Maiduguri, was triggered by the rupture of the Alau dam on the Ngadda River, located 20 kilometers (12 miles) south of the city.
The floodwaters claimed at least 30 lives and displaced 400,000 residents, leaving large parts of the city and surrounding areas in devastation.
NAFDAC’s intervention is aimed at safeguarding public health by preventing the sale and consumption of contaminated drugs.
The agency has mobilized teams to inspect the market and ensure the removal of all compromised pharmaceutical products.
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