Health
Tiny golden bullets could help tackle asbestos-related cancers
Gold nanotubes — tiny hollow cylinders one thousandth the width of a human hair — could be used to treat mesothelioma, a type of cancer caused by exposure to asbestos, according to a team of researchers at the Universities of Cambridge and Leeds.
In a study published today in journal Small, the researchers demonstrate that once inside the cancer cells, the nanotubes absorb light, causing them to heat up, thereby killing the cells.
More than 2,600 people are diagnosed in the UK each year with mesothelioma, a malignant form of cancer caused by exposure to asbestos. Although the use of asbestos is outlawed in the UK now, the country has the world’s highest levels of mesothelioma because it imported vast amounts of asbestos in the post-war years. The global usage of asbestos remains high, particularly in low- and middle-income countries, which means mesothelioma will become a global problem.
“Mesothelioma is one of the ‘hard-to-treat’ cancers, and the best we can offer people with existing treatments is a few months of extra survival,” said Dr Arsalan Azad from the Cambridge Institute for Medical Research at the University of Cambridge. “There’s an important unmet need for new, effective treatments.”
In 2018, the University of Cambridge was awarded £10million from the Engineering and Physical Sciences Research Council to help develop engineering solutions, including nanotech, to find ways to address hard-to-treat cancers.
In a collaboration between the University of Cambridge and University of Leeds, researchers have developed a form of gold nanotubes whose physical properties are ‘tunable’ — in other words, the team can tailor the wall thickness, microstructure, composition, and ability to absorb particular wavelengths of light.
The researchers added the nanotubes to mesothelioma cells cultured in the lab and found that they were absorbed by the cells, residing close to the nucleus, where the cell’s DNA lies. When the team targeted the cells with a laser, the nanotubes absorbed the light and heated up, killing the mesothelioma cell.
Professor Stefan Marciniak, also from the Cambridge Institute for Medical Research, added: “The mesothelioma cells ‘eat’ the nanotubes, leaving them susceptible when we shine light on them. Laser light is able to penetrate deep into tissue without causing damage to surrounding tissue. It then gets absorbed by the nanotubes, which heat up and, we hope in the future, could be used to cause localised cancer-cell killing.”
The team will be developing the work further to ensure the nanotubes are targeted to cancer cells with less effect on normal tissue.
The nanotubes are made in a two-step process. First, solid silver nanorods are created of the desired diameter. Gold is then deposited from solution onto the surface of the silver. As the gold builds-up at the surface, the silver dissolves from the inside to leave a hollow nanotube.
The approach advanced by the Leeds team allows these nanotubes to be developed at room temperature, which should make their manufacture at scale more feasible.
Professor Stephen Evans from the School of Physics and Astronomy at the University of Leeds said: “Having control over the size and shape of the nanotubes allows us to tune them to absorb light where the tissue is transparent and will allow them to be used for both the imaging and treatment of cancers. The next stage will be to load these nanotubes with medicines for enhanced therapies.”
Story Source:
Materials provided by University of Cambridge. The original story is licensed under a Creative Commons License. Note: Content may be edited for style and length.
The Oyo State Ministry of Health has closed two hospitals in Saki West Local Government Area following a suspected outbreak of Lassa fever, which has claimed four lives.
The fatalities, confirmed by the Oyo State Rapid Response Team (RRT), include three males and a 32-year-old female who was preparing for her wedding. The closure of the hospitals aims to contain the spread of the disease and ensure thorough decontamination.
In a press statement issued by the Commissioner for Information and Orientation, Dotun Oyelade, the State Commissioner for Health, Dr. Oluwaserimi Ajetunmobi, revealed that the RRT was dispatched to Saki following distress calls from residents reporting mysterious deaths.
Findings and Immediate Actions
The RRT, comprising health officials, representatives from WHO and the Red Cross, and local health authorities, conducted a comprehensive investigation into the outbreak.
Preliminary findings suggest that an apprentice at one of the affected hospitals, who had recently returned from Iwajowa Local Government Area, might have introduced the infection.
The team disclosed that the deceased exhibited symptoms consistent with Lassa fever, such as craniofacial bleeding. The hospital owner, who was among the deceased, initially self-medicated with antimalarials and antibiotics before seeking hospital care when his condition worsened.
Containment Measures
Both the hospital where the fatalities occurred and the facility that admitted the hospital owner were shut down for decontamination.
Contact tracing efforts are ongoing, focusing on high-risk individuals who had contact with the deceased during their illness or burial.
Affected health workers were trained on Infection Prevention and Control (IPC) protocols, and public awareness campaigns were conducted to educate residents about Lassa fever.
Samples have been collected from a symptomatic individual, pending laboratory confirmation. Line-listing of contacts is underway to identify potential cases and prevent further spread.
Collaborative Efforts
The RRT also paid an advocacy visit to the Okere of Saki’s palace to brief traditional authorities on the situation. Local government officials in Saki West were engaged to coordinate containment strategies.
Reports indicate that while the outbreak initially affected Saki West, it has extended to Iwajowa and Kajola Local Government Areas.
Disease Surveillance and Notification Officers (DSNOs) in the affected LGAs have been instructed to commence preliminary containment measures as the State RRT ramps up its response.
Call for Vigilance
The Ministry of Health has urged residents to remain vigilant, report any symptoms suggestive of Lassa fever, and adhere to preventive measures.
These include proper hygiene practices, avoiding contact with rodents, and seeking medical attention promptly if symptoms arise.
A member representing Ibarapa East/Ido federal constituency of Oyo State at the House of Representatives, Engr. Aderemi Oseni, has announced a plan to launch a “Mobile Clinic” programme aimed at providing essential healthcare services directly to rural communities across the constituency.
Scheduled to begin in the first quarter of 2025, this initiative underscores Oseni’s commitment to expanding healthcare access, particularly for underserved populations.
Speaking on Saturday at the 10th-anniversary celebration of God’s Knot Hospital in Ologuneru, Ibadan, the lawmaker, who also chairs the House Committee on the Federal Roads Maintenance Agency (FERMA), highlighted the programme’s primary objective: bringing healthcare closer to the people.
“Every community deserves attention; healthcare should never be bound by geographical barriers,” Oseni stated.
He explained that the mobile clinics would deliver essential health check-ups, screenings, and preventive care in remote areas, allowing residents to access quality healthcare without traveling long distances.
As part of his broader healthcare agenda, Oseni informed, through a statement by his media aide, Idowu Ayodele, that he has already facilitated the construction of two fully equipped maternity centers within his constituency, both slated for commissioning before December 2024. He also disclosed plans to establish two modern general hospitals in 2025, further strengthening his commitment to building a healthier community.
The lawmaker expressed interest in collaborating with God’s Knot Hospital on the mobile clinic project, calling for partnerships to support sustainable healthcare initiatives that enhance the quality of life for vulnerable populations in the constituency.
“I resonate deeply with the mission of God’s Knot Hospital,” Oseni shared, adding that such partnerships would significantly improve healthcare in Oyo State”.
The anniversary event attracted distinguished guests, including former Ondo State Governor Dr. Olusegun Mimiko, whom Oseni commended for his contributions to healthcare, particularly through the Mother and Child Hospitals that transformed maternal and child healthcare in Ondo State.
Oseni urged philanthropists, government bodies, and international organizations to support healthcare projects like the upcoming mobile clinics, emphasising that the improvement of healthcare services is a shared responsibility.
The National Agency for Food and Drug Administration and Control (NAFDAC) has ordered the immediate closure of the Gomboru drug market in Maiduguri following severe flooding that submerged the area and contaminated the drugs sold within the market.
In a statement posted on its official X handle, NAFDAC disclosed that the decision was made after reports surfaced that contaminated drugs, which had been washed and sun-dried for resale, were being sold at the market.
“After the recent flooding in Maiduguri that submerged the Gomboru drug market where contaminated drugs were washed and sun-dried for resale, the @DGatNAFDAC ordered the immediate closure of the market to conduct a thorough shop-to-shop removal of these compromised drugs,” the agency wrote.
The flooding, which ravaged Maiduguri, was triggered by the rupture of the Alau dam on the Ngadda River, located 20 kilometers (12 miles) south of the city.
The floodwaters claimed at least 30 lives and displaced 400,000 residents, leaving large parts of the city and surrounding areas in devastation.
NAFDAC’s intervention is aimed at safeguarding public health by preventing the sale and consumption of contaminated drugs.
The agency has mobilized teams to inspect the market and ensure the removal of all compromised pharmaceutical products.
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